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Interferon therapy shifts natural killer subsets among egyptian patients with chronic hepatitis C BJID
Fathy,Amal; Eldin,Mohamed Mohy; Metwally,Lobna; Eida,Mohamed; Abdel-Rehim,Marwa; Esmat,Gamal.
Natural killer cells can be divided into five subpopulations based on the relative expression of CD16 and CD56 markers. The majority of natural killer cells are CD56dim, which are considered to be the main cytotoxic effectors. A minority of the natural killer cells are CD56bright, and function as an important source of immune-regulatory cytokines. Shifts of these subsets have been reported in patients with chronic hepatitis C virus infection. We sought to investigate the shift of natural killer subsets among Egyptian patients with chronic HCV and to analyze the influence of interferon therapy on this shift. We applied a flow cytometric analysis of peripheral blood natural killer subsets for 12 interferon-untreated and 12 interferon-treated patients with...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Natural killer cells; Natural killer subsets; Chronic hepatitis C; Innate immunity; Interferon.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400015
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